Endocrine Abstracts

Energy homeostasis is controlled by neural, endocrine and adipocyte factors and CNS plays a key role in this control. We have previously observed that ovariectomized (OVX) rats treated with estradiol have lower body weight gain associated with an increased hypothalamic CRF mRNA expression. We investigated the role of CRF on activation of hypothalamic CART neurons by leptin in estradiol-treated OVX rats. Female Wistar rats (200–250 g) were subjected to both OVX and cannula...

Besides its critical functions as a reproductive hormone, 17β-estradiol (E2), plays an important role in the control of energy homeostasis. In experimental animals, reduction of circulating estrogen levels by bilateral ovariectomy leads to the development of obesity, which can be reversed or prevented by E2 treatment. E2 effects on energy balance resemble many similarities to the actions of leptin, key molecule involved in the control of e...

Repeated exposure to lipopolysaccharide (LPS) leads to endotoxin tolerance. Desensitization of hypophagia in response to repeated exposure to endotoxin is related to an inability of leptin to phosphorylate STAT-3 protein. Protein tyrosine phosphatase 1B (PTP1B) activity is known to contribute to leptin resistance by inhibiting leptin signaling. In this study, we induced endotoxin tolerance, injecting repeated LPS doses (6LPS) (100 μg/kg, i.p.) in comparison with single (1...